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. 2021 Jan 1;11(2):540–554. doi: 10.7150/thno.49517

Figure 5.

Figure 5

Local HT40 suppressed tumor progression and improved the infiltration of T lymphocytes. (A) Time course of treatment effects on tumor volumes through 21 days post-inoculation and (B) Tumor weights at time of harvest in mice unilaterally inoculated with B16F10 cells in the right flank regions. HT40 inhibited tumor growth significantly vs. that of the respective controls (C) HT, αCD40, and HT40 enhanced the populations of tumor infiltrating leucocytes (TILs) compared to control in the harvested tumors of surviving mice. Overall, HT40 demonstrated the highest infiltration rates compared to the other groups. (D) HT40 induced a higher percentage of CD3+ T cell population than the control. (E) Frequency of CD8+ T cells in HT40 group was 2-folds higher compared to the HT and control group. Results are shown as mean ± SEM, n=3-5 per group. One-way ANOVA followed by Tukey's multiple comparison was used for data analysis. * p < 0.05, ** p<0.01.