Figure 6.

HT40 augmented the T cell functions in treated tumors. (A and B) HT40 promoted IFNγ (~2-fold) and Granzyme B (~4-fold) secretion from CD8+ T cells in the treated tumors. (C) Ratio of cytotoxic CD8+ T cells and immunosuppressive regulatory T (Treg) cells in tumors increased by 2.5 and 5-fold with αCD40 and HT40 compared to the untreated controls, respectively. Data are shown as mean ± SEM, n=3-5 per treatment group, * p < 0.05, ** p < 0.01. Data were analyzed by One-way ANOVA followed by Tukey's multiple comparisons; changes between control and treatments in Figure 6C were analyzed using an unpaired t test assuming unequal variance.