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. 2021 Jan 1;11(2):824–840. doi: 10.7150/thno.49600

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Combination of W2014-S and gefitinib suppressed tumor growth. Nu/nu mice were bearing PC-9/GR xenografts and treated with W2014-S (i.p. 10 mg/kg/d) and/or gefitinib (i.g. 50 mg/kg/d) for 21 d. (A) Tumor volume. Data were expressed as mean ± SEM, n=6. ^*P < 0.05, ^**P < 0.01, *^**P < 0.001. (B) Tumor weight. Data were expressed as mean ± SEM, n=6. ^*P < 0.05, ^**P < 0.01, *^**P < 0.001. (C) Tumor size and appearance. (D) The expressions of pY1068-EGFR, EGFR, pY705-STAT3 and STAT3 of PC-9/GR xenografts were detected by western blot. (E) IHC was used to detect the protein levels of pY705-STAT3, pY1068-EGFR and Ki-67 of PC-9/GR xenografts, and scale bar was 150 μm.