Table 1.
Preliminary Pharmacokinetic Parameters for W2014S a
| Parameter | 3 mg/kg iv | 10 mg/kg po |
|---|---|---|
| CL (mL min-1kg-1) | 205.8 | |
| Vss (L/kg) | 77.542 | |
| T1/2 (h) | 13.6 | 1.46 |
| Tmax (h) | 1.67 | |
| Cmax (ng/mL) | 23.8 | |
| AUC0-last (ng•h/mL) | 222 | 54.6 |
| AUC0-inf (ng•h/mL) | 244 | 56.1 |
| F (%) | 7.39 |
aValues are the average of three runs. Vehicle: DMSO/0.5% HPMC (5/95, v/v/). CL, clearance; Vss, volume of distribution; T1/2, half-life; Tmax, time of maximum concentration; Cmax, maximum concentration; AUC, area under the plasma concentration-time curve; F, oral bioavailability.