Pre-therapeutic [68Ga]Pentixafor-PET/MRI and [18F]FDG-PET/MRI of an 82-year-old female MCL patient. [68Ga]Pentixafor-PET detects considerably more nodal lymphoma manifestations than [18F]FDG-PET, and stronger tracer uptake in several lesions/regions. All lymph nodes with focal increased [68Ga]Pentixafor uptake corresponded to clearly enlarged lymph nodes on diffusion-weighted MRI (DWI). Representative examples of such [68Ga]Pentixafor-PET-positive lesions with no or low [18F]FDG uptake, but obvious lymphadenopathy on DWI, are marked by blue arrowheads (left axially, retroperitoneal/periaortic, and right pelvic regions).