Figure 2.

Pre-therapeutic [⁶⁸Ga]Pentixafor-PET/MRI and [¹⁸F]FDG-PET/MRI of a 61-year-old male MCL patient. While the majority of supra- and infradiaphragmatic nodal lymphoma manifestations show both an increased [⁶⁸Ga]Pentixafor and [¹⁸F]FDG uptake, the extranodal gastric lymphoma manifestation and an adjacent enlarged lymph node (blue arrowheads) are only positive on [⁶⁸Ga]Pentixafor-PET, but not on [¹⁸F]FDG-PET. Diffusion-weighted MRI (DWI) confirmed the presence of both lesions, which show a low signal on the apparent diffusion coefficient (ADC) map, reflecting the high cell density typically observed in lymphomas.