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. 2021 Jan 1;11(3):1295–1309. doi: 10.7150/thno.50150

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Bulk RNA-Seq transcriptome analysis of tumor-infiltrating CD11b⁺ cells in response to inhibition of NHE1 in combination with TMZ therapies. (A) Experimental protocol showing isolation of CD11b⁺ cells from GL26 tumor-bearing brain. (B) PCA plot showed Veh, HOE, TMZ, and T+H treated brains separated by their top three principal components. (C) Venn diagram identified genes of interests for downstream pathway analysis. (D) Volcano plots illustrate the gene expression pattern detected (log2 fold change 1.5 and p-value < 0.05). (E) Enrichment analysis showing significantly altered top canonical pathways by using Ingenuity pathway analysis software. (F-G) Box plot showing expression of OXPHOS and proinflammatory genes presented as normalized counts. Data are mean ± SEM, n = 3 mice/group. *p < 0.05 vs indicated.