Figure 4.

Graphical representation of active clinical trials of mAb-based combinatorial targeting in solid tumors. We searched for active clinical trials from the clinical trial site (https://clinicaltrials.gov/) with keywords solid tumors, antibodies plus chemotherapy, cytokines, and kinase inhibitors. These combinations are categorized as cocktails of mAbs, mAb+ chemotherapy, mAb+ kinase inhibitors, mAb+ cytokines, and multiple combinations where the mixture has more than two drugs. A. Each column of the graph represents the total number of clinical trials (y-axis) for each category of combination (x-axis). Different colors in each column represent target antigens for that category. B. Pie chart shows the number of mAb-based combination therapy trials for each class of target antigen(s) in solid tumors (colored separately).