Table 2.
Diagnostic value of PD-L1 expression in thyroid cancer compared to benign lesions
| Histology | Total | PD-L1 Staining | Frequency of PD-L1 positivity | References | ||
|---|---|---|---|---|---|---|
| Ab (Company) | Interpretation | Percentage (%) | p-value | |||
| Thyroid carcinoma | 185 | E1L3N (CST) |
TC >> Benign Intracellular > Cell surface |
66.5 / 40 | - | 48 |
| Benign nodules | 56 | 17 / 10 | ||||
| Thyroid cancer, PTC | 260 | Ab174838 (Abcam) |
WDTC >> healthy Subcellular localization; Not specified |
52.3 | p < 0.001 | 49 |
| Corresponding healthy tissue | 260 | MABC290 (Millipore) | 36.9 | |||
| Thyroid cancer | Ab 82059 (Abcam) |
WDTC > adenomas >> healthy (quantitative) Intracellular |
50 | |||
| PTC | 253 | 82.5 | IHC qualitative | |||
| FTC | 40 | 87.5 | > 0.05 | |||
| Benign | 119 | |||||
| Healthy tissue | 5 | 33.3 | IHC quantitative | |||
| Benign goiters | 58 | 78.4 | < 0.0001 | |||
| Follicular adenomas | 56 | 84.3 | mRNA < 0.0001 | |||
| Invasive EFVPTC | 45 | E1L3N (CST) | Invasive EFVPTC >> NIFT- P; Intracellular | 69 | < 0.001 | 52 |
| NIFT- P | 52 | 31 | ||||
| Thyroid cancer | 113 | 22C3 (Dako) |
WDTC > adenomas >> healthy Invasive EFVPTC>> NIFT- P Intracellular and cell surface |
58.4 | - | 54 |
| PTC | 82 | 59.7 | ||||
| FTC | 2 | 0 | ||||
| invasive EFVPTC | 29 | 58.6 | ||||
| NIFT- P | 12 | 0 | ||||
| Benign | 81 | 16 | ||||
| Goiters | 20 | 0 | ||||
| Follicular adenomas | 48 | 0 | ||||
| Oncocytic adenomas | 13 | 100 | ||||
| ATC | 20 | SP263 (Ventana) / MAB 1561 (R&D) |
↑ ATC progression > Poorly DC > PTC > healthy (% depends on Ab) Intracellular and cell surface |
65 / 90 | - | 51 |
| Corresponding initial tumor | ||||||
| Classical PTC | 13 | 0 / 0 | ||||
| Poorly differentiated insular tumors | 10 | 0 / 36 | ||||
| Corresponding healthy tissue | 17 | 0 / 23.5 | ||||
Abbreviations: ATC, Anaplastic thyroid carcinoma; EFVPTC, Encapsulated follicular variant of papillary thyroid carcinoma; FTC, Follicular thyroid carcinoma; IHC, Immunohistochemistry; NIFT-P, Non-invasive follicular thyroid neoplasm with papillary-like nuclear features; PD-L1: Programmed cell death-ligand 1; PTC, Papillary thyroid carcinoma, WDTC, Well-differentiated thyroid carcinoma (including PTC and FTC). Statistical significance: p < 0.05. A dash is given when the association was not specifically searched for.