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. 2021 Jan 1;11(3):1249–1268. doi: 10.7150/thno.48787

Figure 4.

Figure 4

Wnt5a and Wnt11 are involved in cardiac fibrosis during pressure overload. (A-B), Western blot analysis of Col1, MMP2, MMP9, and TGF-β1 expression in CFs treated with Wnt5a or Wnt11 at 0, 10, or 50 ng/mL. *p < 0.05; **p < 0.01; n = 3/each group. (C), Western blot analysis of Wnt5a and Wnt11 in stretched CMs pre-transfected with si-Scramble (sh-NC) or si-Wnt5a plus si-Wnt11 (si-Wnt5a/11). The conditioned medium from the two groups of CMs was used to treat CFs for 24 h. Col1, MMP9, TGF-β1, α-SMA, and p-smad2/3 were analyzed by Western blotting. **p < 0.01; ***p < 0.001. n = 3/each group.