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. 2021 Jan 1;11(3):1249–1268. doi: 10.7150/thno.48787

Figure 8.

Figure 8

Protease inhibitor attenuates cardiac protection in cardiomyocyte-specific LRP6-overexpressing mice under pressure overload. (A), Western blot analysis of p-LRP6, LRP6, Wnt5a, Wnt11, Col1, Col3, MMP9 and TGF-β1 in the heart tissue. *p < 0.05; **p < 0.01; ***p < 0.001; n = 3/each group. (B), Masson staining of heart tissue and quantitative analysis of fibrosis area. The upper lane: bar = 2 mm; The lower lane: bar = 100 µm, *p < 0.05; **p < 0.01; n = 7-10 /each group. (C), Fraction shortening (FS) in mice. *p < 0.05; **p < 0.01; n = 8/ each group.