Figure 1.

Expression of scavenger receptors in lung tumors. A) Single-cell RNAseq was pooled from 7 patients with lung cancer and automatically clustered according to gene expression profile (and thus cell-type) using the SPRING algorithm. Each data point represents a single-cell. At bottom, magnification of the MΦ/monocyte/DC cluster can be further categorized into polarization subtypes. From GSE127465 and SPRING analysis in ³⁷. B) Corresponding to A, expression of the scavenger receptor type a (SR-AI/II, also known as MΦ scavenger receptor 1, MSR1) is shown in green. C) From data in A, a panel of 30 scavenger receptors ¹⁹⁴ is plotted as a function of average (x-axis) and relatively selective (y-axis) expression in the MΦ/Mo/DC cluster. D) Immunohistochemistry of MSR1 in a biopsied lung adenocarcinoma, showing staining consistent with myeloid expression (from the Human Protein Atlas v19.3 ¹⁹⁵).