Figure 9.

Mapping carboxylesterase expression using the Human Cell Landscape. A) Clustering of scRNAseq data from the human cell landscape project ²⁹ shows >700,000 individual cells colored according to their tissue of origin. Epithelial cells from the intestine (primarily EpCAM+ cells including from the colon, rectum, jejunum, and duodenum) and myeloid cells from the lung (primarily CD68+ CD206+ cells, referred to here as lung MΦ) are highlighted. B) CES1 is found expressed in the cluster of cells that includes high levels of lung MΦ, and is relatively absent in intestinal epithelium. C) Expression of CD206 is high in the cluster of CES1+ cells identified as lung MΦ, but is not restricted to that population. D) CES2 is highly expressed in the intestinal epithelium compared to lung MΦ. See CellXGene and https://db.cngb.org/HCL/ for software to generate plots, described in ²⁹.