Table 1.
List of microfluidic cancer model about mimicking the cascade events of tumor progression
| Aim of study | Culture model type | Cancer type | Notes | Ref. |
|---|---|---|---|---|
| Tumor-like transformation | 2D culture | Lung cancer | Studying tumor-like transformation of bronchial epithelial cells that are continuously exposed to cigarette smoke extracts | 168 |
| Lesions of ductal carcinoma in situ | 3D culture | Breast cancer | Tumor spheroid co-cultured with mammary fibroblasts and human mammary ductal epithelial cells to mimic 3D structural organization and microenvironment | 169 |
| Angiogenesis | 3D culture | - | Using a newly Sphero-IMPACT platform to culture 3D tumor spheroid and monitor angiogenesis, tumor cell migration and invasion | 9 |
| Extravasation | 3D culture | Breast cancer | Setting up a 3D microvascular network to study human metastatic breast cancer cell extravasation | 28 |
| Extravasation | 3D culture | - | Establishing a human microcirculation model to dynamically monitor the extravasation of several tumor cell line | 27 |
| Extravasation | 3D culture | Breast cancer | Establishing a microvascular network to study the extravasation potential of breast cancer cells in a hypoxia environment | 170 |
| Invasion | 3D culture | Lung cancer | Using composite hydrogel microfibers to quantitatively analyze invasion behavior of tumor cells | 171 |
| Invasion | 3D culture | Breast cancer | Formed a tumor-macrophage bidirectional crosstalk system to evaluate the antagonistic effect of the system on anticancer drugs | 172 |
| Metastatic cancer cell matrix invasion | 3D culture | Breast cancer | Cancer cells co-cultured with endothelial to explore the matrix invasion behavior of metastatic breast cancer cells | 29 |
| Invasion and migration | 3D culture | Breast cancer | Tumor cells co-cultured with patient-derived fibroblast cells and evaluate tumor cell migration and invasion under the influence of tumor-stroma interactions | 173 |
| Invasion and migration | 3D culture | Breast cancer | Through polyelectrolyte complex coacervation process, 3D collagen barrier was formed around cancer cell to mimic the basement membrane and observe cells migration and invasion | 174 |
| Migration | 3D culture | Breast cancer | Tumor spheroid co-cultured with endothelial cells. Using 3D photopatterning to confine cells into gelatin methacrylate (GelMA) hydrogel structures | 175 |
| Metastasis | 3D culture | Breast cancer | Developing a spontaneous “bone-on-a-chip” to study bone metastasis in breast cancer | 26 |
| Metastasis | 2D culture | Breast cancer | Developing a microfluidic blood-tumor barrier model to study brain metastasis in breast cancer | 30 |
| Metastasis | 3D culture | Colon cancer | Developing a multiple 3D tissue construction to study liver metastasis in colon cancer | 176 |
| Metastasis | 3D culture | Colorectal cancer | Using 3D photopatterning technique, researchers developed a microfluidic device that houses lung and liver organoid to mimic lung and liver metastasis in colorectal cancer | 177 |
| Stroma-mediated cell motility | 3D culture | Pancreatic cancer | Tumor spheroid co-cultured with stellate cells in a 7-channel microfluidic plate | 10 |
| Intercellular interactions | 3D culture | Liver cancer | Tumor cell co-cultured with stellate cells | 8 |