Table 4.
Univariate and multivariate analysis of overall survival of two matched cohorts
| Variable | 1:1 match of cHCC-CC (n=131) and HCC (n=131) | 1:1 match of cHCC-CC (n=109) and ICC (n=109) | ||||
|---|---|---|---|---|---|---|
| Univariate: p value | Multivariate: HR (95% CI) | p-value | Univariate: p value | Multivariate: HR (95% CI) | p-value | |
| Sex, male | 0.197 | 0.994 | ||||
| ALB, g/L | 0.991 | 0.554 | ||||
| Tumor size | ||||||
| ≤5 cm | Ref | Ref | Ref | Ref | ||
| >5 cm | 0.949 | <0.001 | 1.3 (0.8, 2.3) | 0.288 | ||
| Satellite lesions | 0.216 | <0.001 | 0.8 (0.4, 1.4) | 0.405 | ||
| Tumor thrombus | 0.816 | <0.001 | 0.7 (0.4, 1.2) | 0.161 | ||
| Lymph node infiltration | ||||||
| Negative | Ref | Ref | Ref | Ref | Ref | Ref |
| Positive | <0.001 | 2.5 (1.1, 5.0) | 0.025 | 0.029 | 1.7 (1.1, 2.5) | 0.028 |
| Differentiation | ||||||
| Well | Ref | Ref | Ref | Ref | Ref | Ref |
| Moderate | 0.594 | 2.5 (0.3, 18.8) | 0.378 | 0.305 | 2.2 (0.3, 16.9) | 0.459 |
| Poor | 0.090 | 8.2 (1.1, 61.3) | 0.040 | 0.012 | 3.8 (0.5, 29.8) | 0.203 |
| Undifferentiated | 0.002 | 35.0 (4.3, 282.0) | <0.001 | 0.013 | 3.4 (0.1, 78.2) | 0.441 |
| 8th AJCC stage | ||||||
| I | Ref | Ref | Ref | Ref | Ref | Ref |
| II | 0.097 | 0.5 (0.2, 1.1) | 0.084 | 0.933 | 1.7 (0.5, 5.7) | 0.367 |
| III | 0.801 | 1.3 (0.6, 2.8) | 0.480 | 0.015 | 2.3 (0.7, 7.3) | 0.164 |
| IV | 0.018 | 2.6 (1.1, 6.0) | 0.025 | 0.014 | 2.9 (0.9, 9.7) | 0.082 |
| Margin, R1 | 0.020 | 2.3 (1.3, 4.1) | 0.005 | 0.755 | 0.8 (0.4, 1.5) | 0.466 |
| Surgical method | ||||||
| Major resection | Ref | Ref | Ref | Ref | Ref | Ref |
| Minor resection | 0.061 | 0.6 (0.4, 0.9) | 0.015 | 0.002 | 0.9 (0.5, 1.8) | 0.829 |
| Resection+ Ablation | 0.033 | 2.2 (0.6, 7.7) | 0.237 | 0.109 | 0.8 (0.2, 3.5) | 0.720 |
| Liver transplantation | 0.532 | 0.3 (0.1, 1.4) | 0.127 | 0.322 | 0.4 (0.1, 2.7) | 0.997 |
| Postoperative TACE | ||||||
| Yes | Ref | Ref | Ref | Ref | Ref | Ref |
| No | <0.001 | 2.8 (1.8, 4.3) | <0.001 | <0.001 | 2.5 (1.4, 4.5) | 0.003 |
| Tumor type | ||||||
| cHCC-CC | Ref | Ref | Ref | Ref | Ref | Ref |
| HCC | <0.001 | 0.3 (0.2, 0.6) | <0.001 | - | - | - |
| ICC | - | - | - | 0.061 | 1.3 (0.9, 2.0) | 0.129 |
Abbreviation: cHCC-CC: Combined hepatocellular carcinoma and cholangiocarcinoma; HCC: hepatocellular carcinoma; ICC: intrahepatic cholangiocarcinoma; HR: hazard ratio; CI: confidence interval; Ref: reference; ALB: albumin; AJCC: American Joint Committee on Cancer; TACE: transhepatic arterial chemotherapy and embolization; HR: hazard ratio; CI: confidence interval; ref: reference.