Table 1.

Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis in ampullary cancer microarray by the Database for Annotation, Visualization and Integrated Discovery (DAVID). This table contains only pathways with p values of < 0.0001

KEGG_PATHWAY	p value	Genes
PPAR signaling pathway	2.05E-11	ME1, ACOX2, ACOX1, PPARA, ACADM, CPT2, AQP7, PCK2, PCK1, APOA1, CD36, CYP27A1, HMGCS2, CYP7A1, APOC3, FABP1, FABP2, GK, SCP2, SLC27A2, ACSL6, ACSL5, ACAA1, NR1H3, SLC27A4
Retinol metabolism	2.78E-10	CYP3A4, CYP3A5, CYP3A7, CYP1A1, CYP2C19, CYP2C18, CYP2C9, CYP2B6, ADH6, RDH5, ALDH1A1, UGT1A6, UGT1A8, DGAT1, LRAT, DGAT2, ADH4, UGT2B11, UGT2A3, UGT2B10, UGT2B7, RETSAT
Drug metabolism	4.65E-09	CYP3A4, GSTA2, CYP3A5, CYP3A7, CYP2C19, GSTA5, CYP2C18, CYP2C9, CYP2B6, MAOA, MAOB, CYP2D6, ADH6, FMO4, FMO5, UGT1A6, UGT1A8, ADH4, UGT2B11, UGT2B10, UGT2A3, UGT2B7
Metabolism of xenobiotics by cytochrome P450	1.61E-08	CYP3A4, GSTA2, CYP3A5, CYP3A7, CYP1A1, CYP2C19, GSTA5, CYP2C18, CYP2C9, CYP2B6, CYP2S1, ADH6, DHDH, AKR1C3, UGT1A6, UGT1A8, ADH4, UGT2B11, UGT2B10, UGT2A3, UGT2B7
Steroid hormone biosynthesis	2.24E-06	CYP3A4, CYP3A5, CYP3A7, CYP1A1, HSD17B2, AKR1C3, UGT1A6, UGT1A8, CYP7A1, UGT2B11, HSD11B2, HSD17B3, UGT2B10, SULT1E1, UGT2A3, UGT2B7
Fatty acid metabolism	2.27E-06	ACAA2, ACOX1, ACADSB, CPT2, ACADM, ACADS, ADH4, ADH6, ACAT1, HADHA, ACSL6, ACAA1, ACSL5, HADHB
Linoleic acid metabolism	1.34E-05	CYP3A4, CYP3A5, CYP2J2, AKR1B15, CYP3A7, CYP2C19, CYP2C18, CYP2C9, AKR1B10, PLA2G12B, PLA2G1B, PLA2G2A
Arachidonic acid metabolism	2.79E-05	CYP2J2, CYP2C19, CYP2C18, CYP2C9, CYP2B6, EPHX2, GGT1, AKR1C3, CBR1, PLA2G12B, GPX3, PLA2G1B, PLA2G2A, CYP4F3, CYP4F2
Arginine and proline metabolism	6.70E-05	ACY1, NAGS, OTC, MAOA, SAT2, MAOB, AGMAT, CPS1, CKMT1A, GLS, ARG2, PRODH2, OAT, PRODH

Abbreviations: PPAR, peroxisome proliferator-activated receptor.