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. 2021 Jan 1;18(1):137–149. doi: 10.7150/ijms.48393

Figure 5.

Figure 5

Viability tests of single and combination drug treatment applying tyrosine kinase inhibitor Dasatinib (D), and mTOR inhibitors Rapamycin (R) or Torin-2 (T) in neuroblastoma cell line (A) Kelly, (B) IMR-32, and (C) SK-N-BE(2). Con: Vehicle (DMSO)-treated control cells. Neuroblastoma cells were seeded 24h before treatment. For single treatments the concentrations of the combination treatments was used: (A) Kelly [D+R = 5μM + 2μM; D+T = 1.5μM + 9nM]; (B) IMR-32 [D+R = 0.05μM + 0.13μM; D+T = 1μM + 6nM]; (C) SK-N-BE(2) [D+R = 20μM + 5μM; D+T = 12.5μM + 15nM]. After an incubation of 72h, the cell viability was tested by applying the MTT test as described under Methods. The cell viability was normalized to control-treated cells.