Table 1.
Characteristics of studies included in meta-analysis
| First author | Publish year | Ethnicity | Patients | Controls | Patients/controls | miRNAS | Detected sample |
|---|---|---|---|---|---|---|---|
| Schober | 2014 | Caucasian | Severe TBI | Non-TBI | 8/7 | miR-138, miR-504, miR-16, miR-376a, miR-195, miR-370, miR-320b, miR-135b; miR-744, miR-324-5p, miR-455-3p, let-7a, miR-193b. |
Cerebellar tissue |
| Di Pietro | 2017 | Caucasian | Mild TBI | healthy volunteers | 30/30 | miR-425-5p, miR-502, miR-335 | Serum |
| Di Pietro | 2018 | Caucasian | Concussion | healthy volunteers | 22/10 | let-7i-5p, miR-142-3p, miR-107, miR-27b-3p, miR-135b-5p. | Salivary |
| Redell | 2010 | Caucasian | Severe TBI/mild TBI | healthy volunteers/orthopedic injury patients. | 18/16 | miR-16, miR-92a, miR-765. | Plasma |
| Ko | 2018 | Caucasian | TBI | Healthy controls | 16/20 | miR‐203b‐5p, miR‐203a‐3p, miR‐206, miR‐185‐5p | EV |
| Yang | 2016 | Asian | TBI | Healthy controls | 76/38 | miR-93 | serum |
| Pan | 2019 | Asian | TBI | Non-TBI | 35/21 | miR-155 | Blood and urine |
| O'Connell | 2020 | Caucasian | TBI | Healthy controls | 10/10 | miR-124-3p, miR-219a-5p, miR-9-5p, miR-9-3p, miR-137, and miR-128-3p | Serum |
TBI: traumatic brain injury; EV: brain‐derived extracellular vesicles.