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. 2021 Jan 1;12(2):326–334. doi: 10.7150/jca.48976

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Summarized adverse effects of CAR-T cell therapy. A. In the process of eliminating cancer cells, CAR-T cells released excessive cytokine that exceeded circulatory system load. B. Cancer cells were lysed within a short time and too much intracellular substances were released in hematologic system. C. The cytokines secreted by CAR-T cells could penetrate the blood-brain barrier and leaded to neurotoxicity. D. CAR-T cells eliminated tumor cells through recognizing specific antigen in the surface of tumor cells. On the other hand, it also destroyed normal cells at the same time. E. The genes needed always putted into T cells by virus vectors and it is risky that cells might occurred oncogenic insertion mutations. F. The explanation of abbreviated words in the figure.