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. 2021 Jan 1;12(2):611–621. doi: 10.7150/jca.52234

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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FOXM1 expression had association with poorly prognostic status, and induced cell viability in ovarian cancer. (A) FOXM1 was increased largely in OV tissues. (B) The correlation between FOXM1 levels and survival time in OV was analyzed. (C-D) The level of FOXM1 was detected after knockdown (C) and overexpressed (D) FOXM1 in the SKOV3 and A2780 cells. (E-F) Increased FOXM1 induced cell viability, however, reduced FOXM1 could cause inhibition of SKOV3 and A2780 cell viability. (G-H) Rescue assays revealed circular PVT1 modulates SKOV3 and A2780 proliferation via FOXM1.