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. 2020 Jul 22;13:100243. doi: 10.1016/j.ynstr.2020.100243

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 2 — Dynamic evaluation (A: 1 week; B: 2 weeks; C: 3 weeks; and D: 4 weeks) of behaviors and miR-34a expression in mice receiving fluoxetine (n = 7). ^#p < 0.05 and ^##p < 0.01 compared with the Control-vehicle group. *p < 0.05 and **p < 0.01 compared with the Chronic stress-vehicle group. Two-way ANOVA results of (A) SPT: Stress F(1,24) = 15.70, p < 0.01; Treatment F(1,24) = 0.62, p > 0.05; Interaction F(1,24) = 0.51, p > 0.05; FST: Stress F(1,24) = 11.97, p < 0.01; Treatment F(1,24) = 2.12, p > 0.05; Interaction F(1,24) = 0.11, p > 0.05; miR-34a: Stress F(1,24) = 22.96, p < 0.01; Treatment F(1,24) = 0.27, p > 0.05; Interaction F(1,24) = 0.06, p > 0.05; (B) SPT: Stress F(1,24) = 15.20, p < 0.01; Treatment F(1,24) = 3.02, p > 0.05; Interaction F(1,24) = 4.47, p < 0.05; FST: Stress F(1,24) = 10.35, p < 0.01; Treatment F(1,24) = 2.34, p > 0.05; Interaction F(1,24) = 0.57, p > 0.05; miR-34a: Stress F(1,24) = 8.31, p < 0.01; Treatment F(1,24) = 0.43, p > 0.05; Interaction F(1,24) = 1.48, p > 0.05; (C) SPT: Stress F(1,24) = 14.10, p < 0.01; Treatment F(1,24) = 13.38, p < 0.01; Interaction F(1,24) = 4.48, p < 0.05; FST: Stress F(1,24) = 5.56, p < 0.05; Treatment F(1,24) = 4.38, p < 0.05; Interaction F(1,24) = 3.43, p > 0.05; miR-34a: Stress F(1,24) = 12.78, p < 0.01; Treatment F(1,24) = 4.80, p < 0.05; Interaction F(1,24) = 4.08, p > 0.05; (D) SPT: Stress F(1,24) = 2.73, p > 0.05; Treatment F(1,24) = 5.14, p < 0.05; Interaction F(1,24) = 6.89, p < 0.05; FST: Stress F(1,24) = 9.22, p < 0.01; Treatment F(1,24) = 11.73, p < 0.01; Interaction F(1,24) = 3.66, p > 0.05; miR-34a: Stress F(1,24) = 9.85, p < 0.01; Treatment F(1,24) = 7.16, p < 0.05; Interaction F(1,24) = 5.10, p < 0.05.