Fig. 9.

A summary of the present research work. Left (control mice): Control mice have normal tripartite glutamatergic synapses and numbers of parvalbumin interneurons. Right (GW-exposed mice): GWI/vehicle mice exhibited increased basal extracellular glutamate concentrations, impaired structural integrity and function of glutamatergic synapses, reduced numbers of astrocytes, decreased numbers of parvalbumin interneurons, reduced numbers of newborn neurons, and altered excitatory and inhibitory synaptic transmission. LDN/OSU-215111 effectively normalizes hippocampal abnormalities and behavioral deficits.