Fig. 2.

KOR-specific antagonists, BTRX-084266 and aticaprant, blocked effects of U50,488 on LHb neuron excitability. Insets: Example traces of AP generation in response to +50 pA current injection at baseline + KOR antagonist (black) and post- KOR antagonist + U50,488 (red). A-B. Pretreatment with a KOR-specific antagonist, BTRX-084266 (BTRX), blocked U50,488-induced changes in the excitability in Ih- and Ih+ neurons C-D. Pretreatment with KOR-specific antagonist, aticaprant, blocked U50,488-induced changes in the excitability in Ih- and Ih+ neurons. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)