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. 2020 Oct 18;13:100260. doi: 10.1016/j.ynstr.2020.100260

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 3 — Cannabis vapor self-administration produces biologically relevant concentrations of THC and metabolites in plasma. (A) The mean concentration of THC present in plasma did not differ significantly across sexes or treatment groups. (B and C) The mean concentration of (B) 11-OH-THC and (C) THC-COOH was significantly greater in female rats relative to male rats, irrespective of treatment condition. Error bars represent SEM. The concentration of THC was significantly and positively correlated with the number of vapor deliveries earned for rats in the (D) 75 mg/ml, (E) 150 mg/ml, and (F) 300 mg/ml conditions. Male rats are denoted with closed circles, while female rats are denoted with open circles on the scatterplots. n = 13/sex/group ** denotes p < .01, *** denotes p < 001.