Fig. 1.

CB1 activation at female CA1 dendritic synapses enhances fEPSPs. a) Raw traces from a single experiment and b) time course of averaged experiments show WIN (1 μM) significantly increasing female fEPSPs. Inset: AM251 blocks the WIN-induced increase. c) WIN in the presence of picrotoxin (PTX 100 μM) decreases female fEPSPs, revealing CB1 function on glutamatergic terminals. d) Summary of the WIN, WIN + AM251 and WIN + PTX experiments comparing mean ± SEM baseline responses (last 5 min of the baseline period) and mean ± SEM post-WIN responses (last 5 min of the experiment). Each n = number of slices per experiment. Each * indicates significant differences from baseline responses (p ≤ 0.05), one-way rmANOVAs.