Fig. 7.

Chronic Mild Stress reverses female CB1 function. a) Raw traces from a single experiment (top) and time course of averaged experiments show that WIN activation of CB1 in stress females decreases fEPSPs. Right: Summary comparison of stress and non-stress females. b) Raw traces from a single experiment (top) and time course of averaged experiments reveal that in stress females inverse agonism (AM251) of CB1 increases fEPSPs. Right: comparison of stress and non-stress females. n = number of slices per experiment. Note data for non-stress animals shown comparing the total number of slices across all age ranges (40–65 days old) and representative data from slices aged 52–65 days old(each slice is from different rat). Each * indicates significant differences from baseline responses; #s indicate significant differences between stress and non-stress slices (p ≤ 0.05), mixed, two-way rmANOVA.