Fig. 8.
Chronic Mild Stress impairs female tonic and ERα-driven eCB signaling. a) Raw traces from a single experiment (top) and time course of averaged experiments demonstrate that FAAH inhibition (URB597) stress females has no effect on fEPSPs. Right: comparison of stress and non-stress females. b) Raw traces from a single experiment (top) and time course of averaged experiments show that in stress females MAGL inhibition (JZL184) marginally increases fEPSPs. Right: comparison of stress and non-stress females. c) Raw traces from a single experiment (top) and time course of averaged experiments show that in stress females ERα-driven eCB signaling is absent. Right: comparison of stress and non-stress females. n = number of slices per experiment. Note data for non-stress animals shown comparing the total number of slices across all age ranges (40–65 days old) and representative data from slices aged 52–65 days old (each slice is from different rat). Each * indicates significant differences from baseline responses; #s indicate significant differences between stress and non-stress slices (p ≤ 0.05), mixed, two-way rmANOVA.