Table 2.

Associations between NR3C1 and SLC6A4 methylation and cortisol response to TSST in both groups and in MDD patients Data are analyzed using linear model for repeated measures with cortisol as the outcome measure and methylation as a predictor. All analyses were corrected for age, gender, early life stress and neuroticism. Significance: p < 0.05*

	Both groups (N = 138)				MDD group (N = 80)
	df	F	p	ηp2		df	F	p	ηp2
NR3C1
CpG12	1, 116	1.033	0.312	0.009		1, 63	0.143	0.706	0.002
CpG20	1, 117	0.859	0.356	0.007		1, 63	2.294	0.135	0.035
Amplicon 1 (CpG9-21)	1, 117	0.649	0.422	0.006		1, 63	0.716	0.401	0.011
Amplicon 4 (CpG40-47)	1, 119	1.039	0.310	0.009		1, 65	0.002	0.968	0.000
Total average	1, 119	0.907	0.343	0.008		1, 65	5.451	0.023*	0.077
SLC6A4
CpG8	1, 118	0.004	0.952	0.000		1, 65	0.007	0.936	0.000
CpG10	1, 118	4.081	0.046*	0.033		1, 65	2.873	0.095	0.042
Amplicon 1 (CpG8-12)	1, 118	6.963	0.010*	0.056		1, 65	5.180	0.026*	0.074