Table 1.

Single-gene inborn errors of immunity conferring predisposition to isolated HSE

Gene	Mode of Inheritance	Defect	Clinical findings	References
TLR3	AD	Partial	Forebrain HSE	Lim et al. 2014; Zhang et al. 2007
			IAV pneumonitis	Lim et al. 2019
			VZV ophthalmicus	Liang et al. 2019
	AR	Partial, complete	Forebrain HSE	Guo et al. 2011; Lim et al. 2014
UNC93B1	AR	Complete	Forebrain HSE	Casrouge et al. 2006
TRIF	AD	Partial	Forebrain HSE	Sancho-Shimizu et al. 2011
	AR	Complete	Forebrain HSE	Sancho-Shimizu et al. 2011
TRAF3	AD	Partial	Forebrain HSE	Perez de Diego et al. 2010
TBK1	AD	Partial	Forebrain HSE	Herman et al. 2012
IRF3	AD	Partial	Forebrain HSE	Andersen et al. 2015
SNORA31	AD	Partial	Forebrain HSE	Lafaille et al. 2019
DBR1	AR	Partial	Brainstem HSE	Zhang et al. 2018
			BVE due to IBV, norovirus

HSE: Herpes simplex virus 1 encephalitis; IAV: Influenza A virus; VZV: Varicella zoster virus; IBV: Influenza B virus.