TABLE I.
Molecular targets of second-line tyrosine kinase inhibitors (TKIs) in hepatocellular carcinoma
| TKI | VEGFR | PDGFR | RAF | FGFR | KIT | RET | TIE-2 | MET | AXL | SRC |
|---|---|---|---|---|---|---|---|---|---|---|
| Regorafenib | X | X | X | X | X | X | X | |||
| Cabozantinib | X | X | X | X | X | X | ||||
| Apatinib | X | X | X | X | X |
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