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Current approval status of immunotherapy in hepatocellular carcinoma
| Agent | Type | Line | U.S. FDA | EMA |
|---|---|---|---|---|
| Nivolumab | Anti–PD-1 | 2 | Yes (Sep 2017) | No |
| Pembrolizumab | Anti–PD-1 | 2 | Yes (Nov 2018) | No |
| Atezolizumab | Anti–PD-L1 | 1 | Yes (May 2020)a | Yes (Nov 2020) |
| Ipilimumab | Anti–CTLA-4 | 2 | Yes (Mar 2020)b | No |
In combination with bevacizumab.
In combination with nivolumab.
FDA = Food and Drug Administration; EMA = European Medicines Agency.
