. 2020 Dec 3;21(2):123. doi: 10.3892/etm.2020.9555

Table V.

NRI and IDI analyses for risk reclassification of AKI and mortality in test cohort.

A, AKI
	AUC				IDI		NRI^a
Outcome	Biomarker	Biomarker+ clinical model	Clinical model^b	P-value^c	Value (95% CI)	P-value	Value (95% CI)	P-value
PNI	0.755	0.787	0.672	0.003	0.044 (0.020-0.117)	<0.001	0.169 (0.086-0.382)	<0.001
APSIII	0.694	0.730		0.279	0.021 (0.017-0.076)	<0.001	0.014 (-0.071-0.101)	0.737
PNI+APSIII	0.784	0.801		<0.001	0.712 (0.047-0.158)	<0.001	0.199 (0.120-0.408)	<0.001
B, In hospital mortality
	AUC				IDI		NRI^a
Outcome	Biomarker	Biomarker+ clinical model	Clinical model^b	P-value^c	Value (95% CI)	P-value	Value (95% CI)	P-value
PNI	0.737	0.788	0.663	<0.001	0.015 (-0.011-0.253)	0.066	0.177 (-0.030-0.238)	0.134
APSIII	0.686	0.716		0.001	0.037 (-0.030-0.140)	0.294	0.068 (-0.150-0.332)	0.420
PNI+APSIII	0.779	0.804		<0.001	0.124 (0.022-0.244)	0.028	0.192 (0.007-0.404)	0.046
C, 2-year mortality
	AUC				IDI		NRI^a
Outcome	Biomarker	Biomarker+ clinical model	Clinical model^b	P-value^c	Value (95% CI)	P-value	Value (95% CI)	P-value
PNI	0.735	0.780	0.683	<0.001	0.047 (0.021-0.137)	0.002	0.123 (-0.009-0.356)	0.058
APSIII	0.684	0.711		0.003	0.024 (0.003-0.103)	0.024	0.095 (-0.068-0.286)	0.236
PNI+APSIII	0.777	0.797		<0.001	0.072 (0.033-0.158)	0.002	0.213 (0.037-0.387)	0.026

^aThe NRI is calculated through two-way category by using the event rate of AKI and mortality in the test cohort.

^bThe clinical model for predicting AKI and mortality are composed of age, sex, BMI, hypertension, diabetes, CKD, eGFR, total cholesterol, hemoglobin, leucocyte, mean arterial pressure, triglyceride, serum potassium and serum sodium.

^cBiomarker+clinical model versus clinical model. AUC, area under the receiver-operating characteristic curve; IDI, integrated discrimination improvement; NRI, Net reclassification index; PNI, prognostic nutritional index; APSIII, acute physiology score III; CI, confidence interval; AKI, acute kidney injury.