Table 2.
Measurement of electrophysiological properties under varying INa conditions, measured in one-dimensional fibres based on the O'Hara–Rudy model. APD and CV were measured under control and ischaemic conditions with the latter presented in parentheses. Refractoriness dispersion (ΔERP) was measured as the difference between refractory periods in ischaemic and healthy cells. One-dimensional fibres were stimulated with a frequency of 1 Hz.
| scenario | APD (ms) | ΔERP (ms) | CV (cm s−1) | Vrest (mV) |
|---|---|---|---|---|
| baseline | 240 (169) | 50 | 70.6 (42.9) | −88.0 (−72.9) |
| 50% INa block | 239 (178) | 330 | 60 (30.8) | −88.0 (−72.9) |
| 25% INa block | 241 (170) | 140 | 66.7 (38.7) | −88.0 (−72.9) |
| 25% INa increase | 239 (167) | 20 | 75 (48) | −88.0 (−72.8) |