Time course of cytokine concentrations at baseline, 6 hours after 120 mg/dL alcohol, and 24 hours after 120 mg/dL. Cytokines depicted include interleukin-6 (IL-6), interleukin-8 (IL-8), Tissue Necrosis Factor-α (TNF-α), Interferon gamma (IFN-γ), and interleukin-12 (IL-12). Male smokers indicated by closed blue symbols; male nonsmokers indicated by blue open symbols; female smokers indicated by closed red symbols; female nonsmokers indicated by red open symbols. ** indicates statistically significant post-hoc pairwise comparisons with p<0.01. *** indicates statistically significant post-hoc pairwise comparisons with p<0.001.