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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Neuropathol Appl Neurobiol. 2020 Feb 11;46(5):458–477. doi: 10.1111/nan.12599

Figure 4: Levels of mural cell markers are inversely correlated with Aβ concentrations in human microvessel extracts.

Figure 4:

Aβ concentrations used for linear regression analyses were measured by ELISA and previously published [2]. PDGFRβ and CD13 levels were inversely correlated to vascular Aβ40 concentrations, while a strong trend was noted for α-SMA (A-C). On the contrary, no correlation was observed with vascular Aβ42 (D-F). Statistical analysis: Coefficients of determination (r2) computed after log transformation of both vascular Aβ peptide concentrations and relative optical density values for mural cell markers, ¶¶ p < 0.01. Aβ40 and α-SMA immunoreactivities were detected on larger vessels, with only a scarce colocalization (visible in orange), while CD13-positive signal was found on smaller, capillary-like vessels (G-H). Abbreviations: α-SMA, smooth muscle alpha actin; AD, Alzheimer’s Disease; CD13, aminopeptidase N; Coll IV, type IV collagen; O.D., optical density; PDGFRβ, platelet-derived growth factor receptor β.