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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Neuropathol Appl Neurobiol. 2020 Feb 11;46(5):458–477. doi: 10.1111/nan.12599

Figure 5: CD13 levels are reduced in brain microvessels from old 3xTg-AD mice.

Figure 5:

A-C) Levels of mural cell markers in microvessel extracts from NonTg and 3xTg-AD mice aged 12 and 18 months were determined by Western immunoblotting. Representative photo examples illustrate consecutive bands, with cyclophilin B being shown as loading control. Uncropped gels of all immunoblot assays are shown in Figure S3. CD13 levels are decreased in old 3xTg-AD mice compared to age-matched NonTg mice. No difference was noted for α-SMA and PDGFRβ. Statistical analysis: two-way analysis of variance. Data are represented as bar graphs indicating mean ± S.E.M. Sample size for each group is indicated in the graph bars. Abbreviations: 3x-3xTg-AD, triple transgenic mice; α-SMA, smooth muscle alpha actin; CD13, aminopeptidase N; CypB,cyclophilin B; NT-NonTg, nontransgenic mice; O.D., optical density; PDGFRβ, platelet-derived growth factor receptor β.