Fig. 4.
Histopathological abnormalities associated with fatty infiltration and TIRM hyperintensity. 4A Histopathology sub scores for vastus lateralis and tibialis anterior biopsies obtained from healthy controls and TIRMNEG/FATNEG and TIRMNEG/FATPOS biopsies. More severely abnormalities are present in TIRMNEG/FATPOS biopsies compared to controls and TIRMNEG/FATNEG biopsies. For legibility, p-values are provided for comparison to controls. Comparisons between TIRMNEG/FATNEG and TIRMNEG/FATPOS are all significant at p < 0.05. 4B Distribution of the presence and severity of histopathology sub scores for vastus lateralis and tibialis anterior muscle biopsies obtained from healthy controls and TIRMNEG and TIRMPOS IBM biopsies. Histopathological sub scores were increased in both TIRMNEG and TIRMPOS IBM biopsies compared to controls, independent of the presence or absence of TIRM hyperintensity. 4C TIRMNEG IBM biopsies show either normal or mild-to-moderate inflammation whereas all TIRMPOS IBM biopsies show moderate-to-severe inflammation. *p = <0.05 **p = <0.01 / ***p < 0.001 compared to vastus lateralis.