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. 2020 Nov 24;78(3):951–964. doi: 10.3233/JAD-200527

Fig. 5.

Fig. 5

Dendritically targeting interneurons in APP-KI mice have faster action potentials. A) Representative sEPSC recordings in GFP-expressing interneurons in hippocampal slice from control and APP-KI mice. B, C) Frequency (B; p = 0.009, MW), and amplitude (C; p = 0.74, t) of sEPSCs. D) Representative traces of current injections in GFP-expressing interneurons from control (black) and APP-KI mice (red). E) No change in action potential firing rate with increasing current injections (control: n = 24, APP-KI: n = 25). F–H) Resting membrane potential (F; p = 0.41, t), action potential threshold (G; p = 0.32, t), and action potential amplitude (H; p = 0.59, t) in APP-KI and control GFP-expressing interneurons. I–K) Action potential rise time (I; p = 0.0008, t), halfwidth (J; p = 0.014, t), and decay (K; p = 0.13, t) in APP-KI and control GFP-expressing interneurons. L) Representative action potentials of control (black) and APP-KI (red), highlighting the faster AP kinetics in APP-KI interneurons. (Data in B-C: control n = 22, N = 8; APP-KI n = 23, N = 8. Data in D–H: control n = 24, N = 8; Aβ n = 25, N = 8).