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. 2020 Nov 13;7(24):2003036. doi: 10.1002/advs.202003036

Figure 7.

Figure 7

In vivo synergistic antitumor effects in orthotopic glioma‐bearing rats. a) Serial T2WI MRI images of orthotopic glioma (red arrows) within 14 days after treatment with PBS, iRPPA@MnO, iRPPA@TMZ, PPA@TMZ/MnO, and iRPPA@TMZ/MnO. Data are expressed as mean ± SD (n= 6), *p< 0.05; **p< 0.01; ***p< 0.001 versus PBS group,# p< 0.05 for iRPPA@TMZ/MnO group versus other nanodrug groups. b) Tumor volumes of orthotopic glioma for each group of tumor‐bearing rats. c) Survival rates of orthotopic glioma‐bearing rats (n= 6). d) In vivo HE, Ki‐67, and TUNEL analyses of orthotopic glioma at 14 days after different treatments for each group.