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. 2020 Nov 13;7(24):2003036. doi: 10.1002/advs.202003036

Figure 8.

Figure 8

In vivo biosafety, alleviation of tumor hypoxia, and inhibition of MRP‐1 expression. a) Images of major organs stained by H&E in each group receiving different treatments. b) ALT and AST blood biochemistry tests for liver function assessment in tumor‐bearing rats in each group (n= 3). c) CR and BUN blood biochemical analysis for the renal function assessment for each group of tumor‐bearing rats (n= 3). In vivo expressions of d) HIF‐1αand VEGF and e) MRP‐1 in tumor tissues of glioma‐bearing rats observed on CLSM. f) HIF‐1α, VEGF, and MRP‐1 protein expression in tumor tissues of glioma‐bearing rats analyzed by Western blot analysis. e) Quantification of protein expression levels of HIF‐1α, VEGF, and MRP‐1 based on Western blot analysis in tumor tissues. Data are expressed as mean ± SD (n= 3). 1) PBS; 2) iRPPA@TMZ; 3) iRPPA@MnO; 4) PPA@TMZ/MnO; and 5) iRPPA@TMZ/MnO.