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. 2020 Oct 28;7(24):2003584. doi: 10.1002/advs.202003584

Figure 4.

Figure 4

Combining radiation with agents that target the specific cellular pathways offers new tumor treatment strategies. ATR, ataxia telangiectasia and Rad3‐related protein; CA9, carbonic anhydrase 9; Chk1, checkpoint kinase 1; CTLA‐4, cytotoxic T‐lymphocyte‐associated protein 4; DDR, DNA damage response; DNA‐PK, DNA‐dependent protein kinase; HIF‐1‐α, hypoxia‐inducible factor 1‐alpha; MCT 1, monocarboxylate transporter 1; MCT 4, monocarboxylate transporter 4; mTOR, mechanistic target of rapamycin; PARP, poly(ADP‐ribose) polymerase; PD‐1, programmed cell death protein 1; PI3K, phosphoinositide 3‐kinase; NF‐κB, nuclear factor‐kappa‐B. Adapted with permission under the Creative Commons Attribution License.[ 164 ] Copyright 2016, Springer Nature.