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. 2020 Nov 11;11:572373. doi: 10.3389/fphar.2020.572373

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Copyright © 2020 Xiao, Liu, Mu, Zhang, Wang, Zhao, Chen and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pharmacological mechanisms of Salvianolic acid B (Sal B) based on antioxidant effect. Sal B can inhibit the expressions of Tumor necrosis factor (TNF)-α, Cyclooxygenase (COX2) and NADPH oxidase (NOS) by inhibiting TNF-α/Nuclear factor κB (NF-κB) and Toll-like receptor (TLR4)/NF-κ-B pathways, and promote the expression of antioxidant enzymes such as Heme oxygenase-1 (HO-1), NQOD, Superoxide dismutase (SOD) and inhibit the expression of oxidases such as NOX-2, NOX-4, Poly (ADP-ribozyme) polymerase 1 (PARP-1) by the Nuclear factor E2-related factor 2/Kelch-like ECH-related protein 1 pathway, and then inhibit Reactive oxygen species (ROS) generation, improve inflammation, cell apoptosis, autophagy, fibrosis, microcirculation disorders, and stem cell proliferation and differentiation.