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. 2020 Nov 11;11:572373. doi: 10.3389/fphar.2020.572373

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Copyright © 2020 Xiao, Liu, Mu, Zhang, Wang, Zhao, Chen and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanisms of Salvianolic acid B (Sal B) in different chronic inflammatory diseases. In addition to increasing the expression of antioxidant enzymes such as Superoxide dismutase (SOD), CAT, GSH, and reducing the expression of oxidative enzymes such as Cyclooxygenase (COX-2), NADPH oxidase (NOX)-4, iNOS to inhibit the generation of Reactive oxygen species (ROS) and malondialdehyde (MDA), Sal B has been shown to improve chronic inflammation in a variety of disease models, suggesting that its anti-inflammatory and antioxidant effects are closely related.