. 2020 Nov 11;11:572373. doi: 10.3389/fphar.2020.572373

TABLE 5.

The regulation effect of Sal B on microcirculation.

Animal models/cell types	Stimuli	Concentration of Sal B	Mechanisms	References
*Vivo*
spinal Cord injury (rat)	Dural compression	1, 10, 50 mg/kg (i.v.)	TNF-α, NF-κB↓	(Fan et al., 2013)
spinal Cord injury (rat)	Dural compression	1, 10, 50 mg/kg (i.v.)	ZO-1, occludin, HO-1↑	(Fan et al., 2013)
pulmonary Microcirculation disturbance (rat)	LPS	5 mg/kg (i.g.)	E-selectin, ICAM-1, IL-8, TNF-α, MPO, MMP-2, MMP-9↓	(Lin et al., 2013)
pulmonary Microcirculation disturbance (rat)	LPS	5 mg/kg (i.g.)	AQP-1, AQP-5↑	(Lin et al., 2013)
*Vitro*
Primary rat brain microvascular endothelial cells	Glucose	10, 20, 100 μM	ROS, HIF-1α, VEGF↓	(Yang et al., 2016)
Primary rat brain microvascular endothelial cells	Glucose	10, 20, 100 μM	ZO-1, occludin, miR-200b↑	(Yang et al., 2016)
HUVECs	LPS	10 μM	Caveolin-1, p-VE-cadherin↓	(Pan et al., 2015)
HUVECs	LPS	10 μM	F-actin, ZO-1↑	(Pan et al., 2015)

i.g., intragastrically; i.v., intravenous injection.