TABLE 6.
Regulation of Sal B on stem cells.
| Animal models/cell types | Stimuli | Concentration of Sal B | Mechanisms | References |
|---|---|---|---|---|
| Mouse ESCs | LIF | 0.001, 0.01, 0.1, 1 nM | Oct4, Sox2, AP, Nanog, SSEA1, IL-5, IL-11, EGF, CNTF, EPO, IL-6↑ | (Chia Hui Liu et al., 2014) |
| Jak2-Stat3 and EGFR-ERK1/2 signaling pathways↑ | ||||
| Human ESC line H9 | Activin A | 0.5, 1, 10, and 20 μM | ALB, Ki67, β-catenin, LEF1, TCF3, cyclin D1, c-myc, Wnt1, Wnt2, Wnt3, Wnt6, Wnt7a, MMP7↑ | (Chen J. et al., 2018) |
| Notch1, Notch3, Jagged1, Hes1, Hes5, CCL5, CK7↓ | ||||
| Wnt Pathway↑ | ||||
| Notch Pathway↓ | ||||
| Mouse iPSCs | Retinoic acid | 5, 50, 100 μM | Nestin, Cyclin-D, MAP2↑ | (Shu et al., 2018) |
| pβ-catenin↓ | ||||
| PI3K/AKT/GSK3β↑ |
Oct4, Octamer-binding transcription factor 4; Sox2, sex-determining region Y box 2; AP, alkaline phosphatase; SSEA1, stage-specific embryonic antigen one; iPSCs, induced pluripotent stem cells.