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. 2020 Jul 8;37(12):3423–3438. doi: 10.1093/molbev/msaa167

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© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 2. — Scheme of F1 hybrid genotypes to test the role of PRDM9 alleles in F1 hybrid fertility. (A) The laboratory model of (PWD×B6)F1 hybrid sterility. The first parent is female. Hybrid sterility depends on Prdm9 ^msc1/dom² heterozygosity, presence of PWD allele of Hybrid sterility X2 (Hstx2^PWD) on chromosome X and on interaction of homeologous (domesticus/musculus) autosomes. (B) The Hstx2^PWD and Prdm9^dom² alleles interact with the Prdm9 allele from a wild-derived musculus In B6.DX1s×wild-derived musculus F1 hybrid. (C) The same cross as in (B) but Prdm9^dom² is replaced by humanized Prdm9^dom2H, known to restore Prdm9-dependent sterility. (D) The same Prdm9 and Hstx2 genotype as in (A) but Prdm9^dom² is replaced by a wild-derived domesticus allele.