Fig. 4.
Fst enrichment in polymorphic microRNA target sites. Comparisons of the Fst values for SNPs within microRNA target sites with control sites (background sites, see Materials and Methods). For each range of Fst values, the proportion of sites in that range was calculated for the microRNA target sites (Pt) and for the background sites (Pb). The value plotted is the log(Pt/Pb). (A) All targets sites for highly expressed microRNAs (black, dashed line); target sites where the target allele is ancestral (red) and targets sites where the target site is not ancestral (blue). (B and C) As in (A) but for moderately expressed and zero expressed microRNAs, respectively. (D) Regression between absolute latitude in samples human populations and the target allele frequency associated to SNP rs2470102.