Table 1.
Target Allele Frequencies |
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miRnamea | Gene | snpName | Targetb | EASc | AMR | AFR | EUR | SAS | ALL | F st |
miR-92a-3p | PTK6 | rs186332 | d | 0.964 | 0.873 | 0.047 | 0.928 | 0.593 | 0.630 | 0.849 |
miR-518d-5p | MTAP | rs7868374 | a | 0.008 | 0.048 | 0.684 | 0.005 | 0.118 | 0.213 | 0.824 |
let-7a-5p | MTAP | rs7875199 | a | 0.054 | 0.058 | 0.796 | 0.007 | 0.129 | 0.256 | 0.800 |
miR-202-5p | ATP1A1 | rs1885802 | a | 0.043 | 0.127 | 0.811 | 0.034 | 0.045 | 0.256 | 0.791 |
miR-1180-3p | MYEF2 | rs2470102 | a | 0.753 | 0.339 | 0.925 | 0.006 | 0.272 | 0.497 | 0.773 |
miR-24-3p | SCN2B | rs624328 | d | 0.941 | 0.891 | 0.252 | 0.951 | 0.967 | 0.760 | 0.767 |
miR-21-3p | C4orf46 | rs11544037 | a | 0.025 | 0.262 | 0.854 | 0.130 | 0.169 | 0.326 | 0.745 |
miR-130a-3p | SLC30A9 | rs12511999 | a | 0.049 | 0.236 | 0.913 | 0.250 | 0.222 | 0.377 | 0.730 |
miR-513a-3p | TCERG1 | rs3822506 | d | 0.718 | 0.117 | 0.033 | 0.092 | 0.220 | 0.231 | 0.722 |
miR-1296-5p | BCL7C | rs11864054 | a | 0.088 | 0.455 | 0.976 | 0.618 | 0.841 | 0.628 | 0.714 |
miR-192-5p | C12orf65 | rs1533703 | a | 0.998 | 0.726 | 0.149 | 0.769 | 0.795 | 0.651 | 0.707 |
miR-221-5p | FZR1 | rs10155 | d | 0.798 | 0.473 | 0.015 | 0.294 | 0.302 | 0.348 | 0.692 |
miR-7-5p | ENAM | rs7665492 | a | 0.023 | 0.133 | 0.744 | 0.058 | 0.055 | 0.242 | 0.685 |
miR-514a-3p | EXOC5 | rs3742577 | a | 0.114 | 0.125 | 0.845 | 0.119 | 0.121 | 0.311 | 0.683 |
miR-769-5p | ARIH1 | rs11072379 | a | 0.235 | 0.212 | 0.894 | 0.095 | 0.097 | 0.351 | 0.674 |
miR-769-5p | MPHOSPH9 | rs1727314 | a | 0.977 | 0.726 | 0.142 | 0.768 | 0.741 | 0.634 | 0.668 |
miR-381-3p | PLXNA4 | rs6968754 | a | 0.166 | 0.445 | 0.920 | 0.285 | 0.361 | 0.466 | 0.658 |
miR-520d-3p | UBE2Q1 | rs11265634 | a | 0.098 | 0.221 | 0.870 | 0.186 | 0.199 | 0.356 | 0.649 |
miR-513c-5p | CYB5R4 | rs6912739 | d | 1.000 | 0.932 | 0.381 | 0.954 | 0.994 | 0.818 | 0.646 |
miR-335-3p | PLCB2 | rs4257181 | a | 0.446 | 0.899 | 0.987 | 0.991 | 0.911 | 0.853 | 0.643 |
miR-19b-3p | TRNT1 | rs60884103 | d | 0.699 | 0.242 | 0.054 | 0.024 | 0.360 | 0.264 | 0.643 |
miR-22-3p | OPLAH | rs28475718 | d | 1.000 | 0.957 | 0.437 | 0.989 | 0.969 | 0.838 | 0.641 |
miR-335-3p | ANGEL2 | rs41277158 | a | 0.997 | 0.950 | 0.412 | 0.963 | 0.949 | 0.821 | 0.641 |
miR-103a-3p | HEXA | rs11629508 | d | 0.774 | 0.839 | 0.179 | 0.946 | 0.943 | 0.694 | 0.631 |
miR-34a-5p | CDPF1 | rs1053332 | a | 0.001 | 0.169 | 0.746 | 0.194 | 0.082 | 0.276 | 0.631 |
miR-144-3p | CFAP61 | rs1410937 | a | 1.000 | 0.954 | 0.412 | 1.000 | 1.000 | 0.839 | 0.626 |
miR-144-5p | RSU1 | rs6977 | d | 0.895 | 0.921 | 0.275 | 0.982 | 0.932 | 0.760 | 0.625 |
miR-223-3p | PCDH15 | rs11003862 | d | 0.055 | 0.591 | 0.731 | 0.764 | 0.440 | 0.526 | 0.625 |
miR-145-5p | C3orf85 | rs56027044 | d | 0.164 | 0.392 | 0.879 | 0.590 | 0.441 | 0.524 | 0.622 |
miR-509-5p | PKDREJ | rs6007729 | a | 1.000 | 0.937 | 0.421 | 0.963 | 0.964 | 0.825 | 0.621 |
miR-197-3p | GP2 | rs12444232 | d | 0.682 | 0.157 | 0.032 | 0.047 | 0.190 | 0.214 | 0.616 |
miR-200b-3p | PCDH15 | rs11003861 | a | 0.810 | 0.339 | 0.048 | 0.179 | 0.454 | 0.347 | 0.612 |
miR-124-3p | CPSF4 | rs1043466 | d | 0.660 | 0.716 | 0.055 | 0.833 | 0.618 | 0.535 | 0.608 |
miR-381-3p | INAFM2 | rs2289333 | d | 0.554 | 0.308 | 0.007 | 0.090 | 0.153 | 0.204 | 0.607 |
miR-377-3p | OGDHL | rs6816 | a | 0.105 | 0.529 | 0.933 | 0.553 | 0.582 | 0.566 | 0.607 |
Representative microRNA of the family.
This column indicates if the target allele is ancestral (“a”) or derived (“d”).
Target allele frequency for the five superpopulations analyzed (see Materials and Methods for definitions).