Fig 5. Social behavior in a three-chamber test in young adult and middle-aged CD157 KO mice (A–C) and CD38 KO mice (D–F).

(A, D) The sociability stage. Time spent with a social (Str1) or a non-social object (Object). (B, E) The social novel preference stage. Time mice spent with a familiar mouse (Str1) or a novel mouse (Str2). (C, F) Total social time during which mice stayed in the arena with mouse targets. (In CD157KO mice, n = 7 for young adult, n = 6 for middle-aged, in CD38KO mice) Bonferroni’s post hoc comparison or Unpaired t-test, *p < 0.05, **p < 0.01, ****p < 0.0001.