Table 1. Characteristics of the sample regarding sex, waist circumference, lipid profile and methylation levels of the LPL, ADRB3 and MTHFR genes according to different LDL-C estimates and cut-off values.
| Lipid profile | Mean | SD | LDL-C F (mg/dL) <130 <70 | LDL-C F (mg/dL) ≥130 ≥70 | P-value | LDL-C M (mg/dL) <130 <70 | LDL-C M (mg/dL) ≥130 ≥70 | P-value |
|---|---|---|---|---|---|---|---|---|
| Female | - | - | 117 (50%) | 41 (17%) | <0.000*a | 105 (45%) | 53 (22%) | 0.000*a |
| 24 (10%) | 134 (56.8) | <0.000*a | 13 (5%) | 145 (61%) | 0.000*a | |||
| Male | - | - | 61 (26%) | 17 (7%) | <0.000*a | 55 (23%) | 23 (10%) | <0.000*a |
| 17 (7%) | 61 (25.8%) | <0.000*a | 6 (2%) | 72 (30%) | <0.000*b | |||
| Female waist size (cm) | 84.44 | 14.8 | 82.84 ± 14.94 | 88.61 ± 13.81 | 0.019*c | 82.48 ± 15.56 | 88.22 ± 12.58 | 0.010*c |
| 81.08 ± 16.08 | 84.99 ± 14.59 | 0.250c | 74.79 ± 12.87 | 85.31 ± 14.72 | 0.008*c | |||
| Male waist size (cm) | 87.18 | 14.6 | 86.39 ± 15.52 | 90.03 ± 10.25 | 0.259b | 85.13 ± 14.65 | 92.08 ± 13.40 | 0.048*b |
| 83.80 ± 14.13 | 88.05 ± 14.65 | 0.298b | 79.17 ± 13.25 | 87.85 ± 14.54 | 0.177b | |||
| Total cholesterol (mg/dL) | 186.4 | 42.1 | 169.98 ± 28.32 | 236.60 ± 37.30 | <0.000*b | 164.39 ± 24.69 | 232.60 ± 32.40 | <0.000*b |
| 139.29 ± 24.26 | 196.25 ± 38.13 | <0.000*b | 121.84 ± 13.49 | 192.00 ± 38.86 | <0.000*b | |||
| HDL (mg/dL) | 43.78 | 11 | 43.45 ± 11.19 | 44.78 ± 10.43 | 0.413b | 43.36 ± 11.62 | 44.67 ± 9.59 | 0.360b |
| 40.90 ± 13.67 | 44.38 ± 10.29 | 0.129b | 46.37 ± 13.71 | 43.55 ± 10.74 | 0.394b | |||
| Triglycerides (mg/dL) | 138.8 | 73.7 | 132.12 ± 69.19 | 159.38 ± 83.43 | 0.027*b | 129.33 ± 70.12 | 158.80 ± 77.47 | 0.124b |
| 142.37 ± 85.15 | 138.07 ± 71.29 | 0.764b | 115.89 ± 64.34 | 140.83 ± 74.26 | 0.124 b | |||
| LPL gene methylation level (%) | 36% | 19% | 36% ± 20% | 36% ± 17% | 0.901b | 36% ± 19% | 37% ± 18% | 0.632b |
| 34% ± 18% | 38% ± 19% | 0.430 b | 37% ± 23% | 36% ± 19% | 0.919 b | |||
| ADRB3 gene methylation level (%) | 41% | 18% | 42% ± 18% | 38% ± 17% | 0.098b | 43% ± 18% | 39% ± 18% | 0.151b |
| 43% ± 19% | 41% ± 18% | 0.452 b | 52% ± 19% | 40% ± 18% | 0.010*c | |||
| MTHRF gene methylation level (%) | 35% | 18% | 34% ± 18% | 36% ± 17% | 0.487b | 34% ± 18% | 36% ± 18 | 0.381b |
| 31% ± 16% | 36% ± 18% | 0.165 b | 26% ± 10% | 36% ± 18% | 0.031*c |
a: proportions test
b: t-test
*: significant results
c: Mann-Whitney test; -: the calculation does not apply or does not make sense; F: Friedewald; M: Martin; LDL-C: low-density lipoprotein cholesterol.